The following is Dr. Lang’s bibliography. Stay tuned for more great research to come!
Lang JD*. Selleck W, Striker S, Hipschman NA, Kofman R, Karnezis AN, Kommoss FKF, Komoss F, Wendt J, Facista SJ, Hendricks WPD, Orlando KA, Pirrotte P, Raupach EA, Zismann VL, Wang Y, Huntsman DG, Weissman BE, Trent JM. Landscape of super-enhancers in small cell carcinoma of the ovary, hypercalcemic type and efficacy of targeting with natural product triptolide. bioRxiv. 2023 September; doi: 10.1101/2023.09.08.556863. * corresponding author
Raupach EA, Garcia-Mansfield K, Sharma R, Hegde AM, David-Dirgo V, Wang Y, Young Shin C, Tao LV, Facista SJ, Moore R, Lang JD, Zismann VL, Orlando KA, Spillman M, Karnezis AN, Bennett LB, Huntsman DG, Trent JM, Hendricks WP, Weissman BE, Pirrotte P. Novel functional insights revealed by distinct protein-protein interactions of the residual SWI/SNF complex in SMARCA4-deficient small cell carcinoma of the ovary, hypercalcemic type. bioRxiv. 2019 October; doi: 10.1101/794776.
Harwood OE, Matschke LM, Moriarty RV, Balgeman AJ, Weaver AJ, Ellis-Connell AL, Weiler AM, Winchester LC, Fletcher CV, Friedrich TC, Keele BF, O’Connor DH, Lang JD, Reynolds MR, O’Connor SL. CD8+ cells and small viral reservoirs facilitate post-ART control of SIV in Mauritian cynomologus macaques. bioRxiv. 2023 March; doi: 10.1101/2023.03.01.530655. Provisionally accepted at PLOS Pathogens on September 12, 2023.
Lang JD, Nguyen TVV, Levin MK, Blas PE, Williams H, San Roman Rodriguez E, Briones N, Mueller C, Selleck W, Moore S, Zismann VL, Peck K, Hendricks WPD, Espina V, O’Shaughnessy. Pilot clinical trial and phenotypic analysis in chemotherapy-pretreated, metastatic triple-negative breast cancer patients treated with oral TAK-228 and TAK-117 (PIKTOR) to increase DNA damage repair deficiency followed by cisplatin and nab paclitaxel. Biomarker Research. 2023 Jul 25;11(1):73. doi: 10.1186/s40364-023-00511-7. PubMed PMID: 37491309; PubMed Central PMCID: PMC10369813.
Hendricks WPD, Sekulic A, Bryce AH, Murtaza M, Ramos P, Lang JD, Whitsett TG, McDaniel TK, Rockne RC, Banovich N, Trent JM. Cancer Genomics and Evolution. Holland‐Frei Cancer Medicine [Internet]. 2022. p. 1–30. doi: 10.1002/9781119000822.hfcm007.pub2.
Wei J, Zhang J, Wang D, Cen B, Lang JD, DuBois RN. The COX-2-PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas. Cancer Prev Res (Phila). 2022 May 3;15(5):285-296. doi: 10.1158/1940-6207.CAPR-21-0572. PubMed PMID: 35121582; PubMed Central PMCID: PMC9064954.
Halperin RF, Hegde A, Lang JD, Raupach EA; C4RCD Research Group, Legendre C, Liang WS, LoRusso PM, Sekulic A, Sosman JA, Trent JM, Rangasamy S, Pirrotte P, Schork NJ. Improved methods for RNAseq-based alternative splicing analysis. Sci Rep. 2021 May 24;11(1):10740. doi: 10.1038/s41598-021-89938-2. PMID: 34031440; PMCID: PMC8144374.
Ghergurovich JM, Lang JD, Levin MK, Briones N, Facista SJ, Mueller C, Cowan AJ, McBride MJ, Rodriguez ESR, Killian A, Dao T, Lamont J, Barron A, Su X, Hendricks WPD, Espina V, Von Hoff DD, O’Shaughnessy J, Rabinowitz JD. Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer. Med (N Y). 2021 Jun 11;2(6):736-754. doi: 10.1016/j.medj.2021.03.009. Epub 2021 Apr 14. PMID: 34223403; PMCID: PMC8248508.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE. Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines. Clin Cancer Res. 2020 Aug 1;26(15):3908-3917. doi: 10.1158/1078-0432.CCR-19-3797. Epub 2020 Mar 10. PMID: 32156746; PMCID: PMC7415570.
Soldi R, Ghosh Halder T, Weston A, Thode T, Drenner K, Lewis R, Kaadige MR, Srivastava S, Daniel Ampanattu S, Rodriguez Del Villar R, Lang J, Vankayalapati H, Weissman B, Trent JM, Hendricks WPD, Sharma S. The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. PLoS One. 2020 Jul 10;15(7):e0235705. doi: 10.1371/journal.pone.0235705. PMID: 32649682; PMCID: PMC7351179.
Cen B, Lang JD, Du Y, Wei J, Xiong Y, Bradley N, Wang D, DuBois RN. Prostaglandin E2 Induces miR675-5p to Promote Colorectal Tumor Metastasis via Modulation of p53 Expression. Gastroenterology. 2020 Mar;158(4):971-984.e10. doi: 10.1053/j.gastro.2019.11.013. Epub 2019 Nov 14. PMID: 31734182; PMCID: PMC7062589.
Orlando KA, Douglas AK, Abudu A, Wang Y, Tessier-Cloutier B, Su W, Peters A, Sherman LS, Moore R, Nguyen V, Negri GL, Colborne S, Morin GB, Kommoss F, Lang JD, Hendricks WP, Raupach EA, Pirrotte P, Huntsman DG, Trent JM, Parker JS, Raab JR, Weissman BE. Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism. Elife. 2020 Dec 23;9:e59073. doi: 10.7554/eLife.59073. PMID: 33355532; PMCID: PMC7813545.
Lang JD, Hendricks WPD. Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT). Methods Mol Biol. 2018;1706:367-379. doi: 10.1007/978-1-4939-7471-9_20. PMID: 29423809.
Lang JD, Hendricks WPD, Orlando KA, Yin H, Kiefer J, Ramos P, Sharma R, Pirrotte P, Raupach EA, Sereduk C, Tang N, Liang WS, Washington M, Facista SJ, Zismann VL, Cousins EM, Major MB, Wang Y, Karnezis AN, Sekulic A, Hass R, Vanderhyden BC, Nair P, Weissman BE, Huntsman DG, Trent JM. Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition. Clin Cancer Res. 2018 Apr 15;24(8):1932-1943. doi: 10.1158/1078-0432.CCR-17-1928. Epub 2018 Feb 9. PMID: 29440177; PMCID: PMC6526947.
Wang Y, Chen SY, Colborne S, Lambert G, Shin CY, Santos ND, Orlando KA, Lang JD, Hendricks WPD, Bally MB, Karnezis AN, Hass R, Underhill TM, Morin GB, Trent JM, Weissman BE, Huntsman DG. Histone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type. Mol Cancer Ther. 2018 Dec;17(12):2767-2779. doi: 10.1158/1535-7163.MCT-18-0348. Epub 2018 Sep 19. PMID: 30232145; PMCID: PMC6279577.
Wang Y, Chen SY, Karnezis AN, Colborne S, Santos ND, Lang JD, Hendricks WP, Orlando KA, Yap D, Kommoss F, Bally MB, Morin GB, Trent JM, Weissman BE, Huntsman DG. The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type. J Pathol. 2017 Jul;242(3):371-383. doi: 10.1002/path.4912. Epub 2017 Jun 2. PMID: 28444909; PMCID: PMC6857704.
Berry SM, Singh C, Lang JD, Strotman LN, Alarid ET, Beebe DJ. Streamlining gene expression analysis: integration of co-culture and mRNA purification. Integr Biol (Camb). 2014 Feb;6(2):224-31. doi: 10.1039/c3ib40136g. PMID: 24413730; PMCID: PMC3956049.
Lang JD, Berry SM, Powers GL, Beebe DJ, Alarid ET. Hormonally responsive breast cancer cells in a microfluidic co-culture model as a sensor of microenvironmental activity. Integr Biol (Camb). 2013 May;5(5):807-16. doi: 10.1039/c3ib20265h. PMID: 23559098; PMCID: PMC3648339.
Yang B, Bhusari S, Kueck J, Weeratunga P, Wagner J, Leverson G, Huang W, Jarrard DF. Methylation profiling defines an extensive field defect in histologically normal prostate tissues associated with prostate cancer. Neoplasia. 2013 Apr;15(4):399-408. doi: 10.1593/neo.13280. PMID: 23555185; PMCID: PMC3612912.
Berry SM, Strotman LN, Kueck JD, Alarid ET, Beebe DJ. Purification of cell subpopulations via immiscible filtration assisted by surface tension (IFAST). Biomed Microdevices. 2011 Dec;13(6):1033-42. doi: 10.1007/s10544-011-9573-z. PMID: 21796389; PMCID: PMC3314424.
Bhusari S, Yang B, Kueck J, Huang W, Jarrard DF. Insulin-like growth factor-2 (IGF2) loss of imprinting marks a field defect within human prostates containing cancer. Prostate. 2011 Nov;71(15):1621-30. doi: 10.1002/pros.21379. Epub 2011 Mar 22. PMID: 21432864; PMCID: PMC3825178.